Readings

Lecture 1 - Key Concepts in Biochemistry with a Focus on Nucleic Acids

Recent Science article on peptide synthesis:
- Gregor Blaha, Robin E. Stanley and Thomas A. Steitz, "Formation of the First Peptide Bond: The Structure of EF-P Bound to the 70S Ribosome," Science 2009, 325, 966-970.
Identification of DNA's role as the storage form of genetic information:
- Avery, O. T., Macleod, C. M., and McCarty, M., "Studies on the Chemical Nature of the Substance Inducing Transformation of Pneumococcal Types: Induction of Transformation by a Desoxyribonucleic Acid Fraction Isolated from Pneumococcus Type III," J. Exp. Med.1944, 79, 137–158.
Determining the structure of DNA:
- Pauling, Linus and Corey, Robert, "A Proposed Structure for the Nucleic Acids", Proceedings of the National Academy of Science 1953, 39, 84-97.
- Wilkins, M.H.F., Stokes, A.R. and Wilson, H.R., "Molecular Structure of Deoxypentose Nucleic Acids", Nature 1953, 171, 738-740.
- Watson, J.D. and Crick, F.H.C., "A Structure for Deoxyribose Nucleic Acids", Nature 1953, 171, 737-738.
Clarifying the "Central Dogma"
- Crick, F., "Central Dogma of Molecular Biology", Nature 1970, 227, 561-563.
A brief history of the genome
- Le Page, M. (2012), New Scientist, September 15, 2012 (2882), pp30-35.

Lecture 2 - Protein Structure

Protein folding:
- Anfinsen, Christain, "Principles the Govern the folding of Proteins", Science 1973, 181, 223-230. (Anfinsen's Nobel Lecture)
- Akst, Jef, "Public solves Protein Structure: Players of an onlline game that allows users to adjust how proteins are folded have solved a decade-long protein structure mystery.", The Scientist: News & Opinion 2011 Sept. 18.
- Cooper, S., Khatib, F., Treuille, A., Barbero, J., Lee, J., Beenen, M., Leaver-Fay, A., Baker, D., Popović, Z., "Predicting protein structures with a multiplayer online game", Nature 2010 466, 756-760.

Lecture 3 - Hemoglobin: A Case Study of Protein Structure-Function Relationships

Crystal structure of myoglobin
- Kendrew, J.C., Bodo, G., Dintzis, Parrish, R.G. and Wyckoff, H., "A Three-Dimensional Model of the Myoglobin Molecule Obtained by X-Ray Analysis", Nature 1958, 181, 662-666.
Crystal structure of hemoglobin
- Perutz, Max, "RElation Between Structure and Sequence of Haemoglobin", Nature 1962, 194, 914-917.

Lecture 5 - Enzyme Catalytic Strategies

Metabolic Reconstruction
- Zhang, Ying et al., "Three-Dimensional Structural View of the Central Metabolic Network of Thermotoga maritima" Science 2009, 325, 1544-154

Lecture 10 - Signal Transuction and Sensory Systems

G Protein Regulation of Potassium Ion Channels
- Yamada et al, 1998
Fine Tuning the Retinal Photoreceptor
- Sakmar, T. P. " Redder Than Red", Science 2012 338, 1299–1300.
- Wang, W., Nossoni, Z., Berbasova, T., Watson, C. T., Yapici, I., Lee, K. S. S., Vasileiou, C., Geiger, J. H., and Borhan, B. "Tuning the Electronic Absorption of Protein-Embedded All-trans-Retinal", Science 2012 338, 1340–1343.

Lecture 11 - Molecular Motors