Conclusions
     TIM is an enzyme that is used by all organisms that have a glycolytic cycle and has been in use for a very long time (iii).  The fact that TIM makes use of all of the carbons of glucose made it a good candidate for early evolutionary selection.  Since it has been around for such a long time and it is very useful it has has plenty of time to evolve in to the perfect catalysts.  In my research I was unable to find out why there is a second sub unit.  This was not mentioned in any other papers yet I still wonder why it is there.  TIM is a good candidate for this type of research (functions dependence upon structure) because it has a popular folding motif and the action of the hinged lid.  With TIM one is able to explore how secondary structure is put together to form a scaffolding  suitable for the task of interconversion.  Also the active site of TIM possesses a hinged lid that is integral to the function of the enzyme.  I find it interesting that at the molecular level there is a need for such a clamp.  In closing I would like to thank the people who made CHIME such a useful tool also I would like to thank Netscape for creating an easy to use editor.

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Created by Jason Hadrath
hadratjm@UWEC.edu
Student of Dr. W. Gallagher
at the University of Wisconsin at Eau Claire
Chemistry Department



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