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- Lecture 0: A Physical Description of Nature
- Lecture 1: Transport Processes - Sedimentation
- Lecture 2: Calculus Review
- Lecture 3: Thermodynamics I - Heat, Work and Energy
- Lecture 4: Thermodynamics II - Entropy and Free Energy
- Lecture 5: Bioenergetics and Molecular Interactions
- Lecture 6: Proteins - Structure and Function
- Lecture 7: Structure Determination
Lecture 0: A Physical Description of Nature [TOC]
- Reading Assignment: Atkins, P and de Paula, J. (2006) Physical Chemistry for the Life Sciences; Fundamentals [flashpaper]
- Problem assignment: Problem Set 1 [flashpaper]
Lecture 1: Transport Processes - Sedimentation and Diffusion [TOC]
- Reading Assignment: van Holde, Johnson & Ho (1998) Principles of Physical Biochemistry; Chapter 5 [flashpaper]
- Problem assignment: Problem Set 2 [flashpaper]
- Theodor Svedberg (1884-1971) Nobel Prize in Chemistry, 1926
- Wilhelm Ostwald (1853-1932) Nobel Prize in Chemistry, 1909
Lecture 2: Calculus Review [TOC]
- Online Tutorials, Waner and Costenoble [html]
- Problem assignment: Problem Set 3 [flashpaper]
Lecture 3: Thermodynamics I - Heat, Work and Energy [TOC]
- Reading Assignment: Hammes, G; Thermodynamics and Kinetics for the Biological Sciences; Chapter 1 - Heat, Work and Energy [flashpaper]
- Reading Assignment: Atkins, P and de Paula, J.; Physical Chemistry for the Life Sciences; Chapter 1-Biochemical Thermodynamics:The First Law [pdf]
- Problem Set: Problem Set 4 [flashpaper]
- Problem Set: Problem Set 5 [flashpaper]
- Theremodynamic Data Sheets [pdf]
- Overheads: C406-Thermo-I [quicktime and flashpaper]
Lecture 4: Thermodynamics II - Entropy and Free Energy [TOC]
- Reading Assignment: Hammes, G; Thermodynamics and Kinetics for the Biological Sciences; Chapter 2 - Entropy and Free Energy [flashpaper]
- Reading Assignment: Atkins, P and de Paula, J.; Physical Chemistry for the Life Sciences; Chapter 2 - The Second Law [pdf]
- Reading Assignment: Atkins, P and de Paula, J.; Physical Chemistry for the Life Sciences; Chapter 4 - Chemical Equlibrium [pdf]
- Overheads: C406-Thermo-II [quicktime and flashpaper]
- Problem Set: Problem Set 6 [flashpaper]
Lecture 5: Bioenergetics and Molecular Interactions [TOC]
Bioenergetics
- Reading Assignment: Nelson, D & Cox, M: Lehninger's Biochemistry, 4thEdition [pdf]
- Overheads: C406-Bioenergetics [quicktime and flashpaper]
Interactions
- Reading Assignment: Atkins, P; The Elements of Physical Chemistry [pdf]
- Overheads: C406-Interactions [quicktime and flashpaper]
Lecture 6: Proteins - Structure and Function [TOC]
Lecture 7: Structure Determination [TOC]
X-ray Crystallography
- Lecture Notes: [pdf]
- Lecture Overheads [quicktime and pdf]
- Reading Assignment: Gale Rhodes; Crystallography Made Crystal Clear, 2ndEd.; Chapters 1 - Model and Molecule & Chapter 2 - An Overview of Protein Crystallography [pdf]
- Companion Web Site for Rhodes' Crystallography Made Crystal Clear [html]
- Kevin Cowtan's Book of Fortran [html]
- Kevin Cowtan's Interactive Structure Factor Applet [html]
- Bernhard Rupp's Crystallography 101 site [html]