Hartselab Research-Publications at UW-EC

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*Undergraduate coauthors 
  1. *Behling LA, Hartsel SC, Lewis DE, DiSpirito AA, Choi DW, Masterson LR, Veglia G, Gallagher WH. "NMR, mass spectrometry and chemical evidence reveal a different chemical structure for methanobactin that contains oxazolone rings." J Am Chem Soc. 2008 Sep 24;130(38):12604-5.
  2. Choi DW, Semrau JD, Antholine WE, Hartsel SC, *Anderson RC, *Carey JN, *Dreis AM, *Kenseth EM, *Renstrom JM, *Scardino LL, *Van Gorden GS, *Volkert AA, *Wingad AD, *Yanzer PJ, McEllistrem MT, de la Mora AM, DiSpirito AA."Oxidase, superoxide dismutase, and hydrogen peroxide reductase activities of methanobactin from types I and II methanotrophs." J Inorg Biochem. 2008 Aug;102(8):1571-80.
  3. Dong W. Choi , Young S. Do, Corbin J. Zea, , Marcus T. McEllistrem, Sung-W. Lee, Jeremy D. Semrau, Nicola L. Pohlb, Clint J. Kistinga, Lori L. *Scardino, Scott C. Hartsel, Eric S. Boyd, Gill G. Geesey, Theran P. *Riedel, Peter H. Shaf, Kim A. *Kranski, John R. *Tritsch, William E. Antholine and Alan A. DiSpirito “Spectral and thermodynamic properties of Ag(I), Au(III), Cd(II), Co(II), Fe(III), Hg(II), Mn(II), Ni(II), Pb(II), U(IV), and Zn(II) binding by methanobactin from Methylosinus trichosporium OB3b”, Journal of Inorganic Biochemistry; 2006, 100 2150–2161.
  4. Choi, D. W.; Zea, C. J.; Do, Y. S.; Semrau, J. D.; Antholine, W. E.; Hargrove, M. S.; Pohl, N. L.; Boyd, E. S.; Geesey, G. G.; Hartsel, S. C.; Shafe, P. H.; McEllistrem, M. T.; Kisting, C. J.; *Campbell, D.; *Rao, V.; de la Mora, A. M.; DiSpirito, A. ASpectral, Kinetic, and Thermodynamic Properties of Cu(I) and Cu(II) Binding by Methanobactin from Methylosinus trichosporium OB3b Biochemistry; (Article) 2006   45(5); 1442-1453.
  5.  Choi, D., William E. Antholine, Jeremy D. Semrau, Young S. Do, Clint J. Kisting, Corbin J. Zea, Mark S. Hargrove, Nicola L. Pohl, Eric S. Boyd, Damon *Campbell, Vinay *Rao, Scott C. Hartsel, and Alan A. DiSpirito. Spectral and Metal Binding Properties of Methanobactin from Methylosinus trichosporium OB3b. Microbiology 2005151: 3417-3426.
  6. Turtinen L, *Bremer L, *Prall D, *Schwartzhoff J, and S.C. Hartsel “Distinct cytokine release profiles in human endothelial and THP-1 macrophage-like cells exposed to different Amphotericin B formulations “Immunopharmacology and Immunotoxicology 2005 27: 85-93.
  7.   Lloyd W. Turtinen , David N. Prall* , Lindsay A. Bremer* , Rachel E. Nauss*  and Scott C. Hartsel "Antibody Array Generated Cytokine Release Profiles from THP-1 Monocytic Cells Exposed to Different Amphotericin B Formulations" Antimicrobial Agents and Chemotherapy, (2004) Feb;48(2):396-403. 
  8.  Bartlett, Karen , Edwin Yau*, Scott C. Hartsel, Alison Hamer, Gina Tsai, Dan Bizzotto and Kishor M. Wasan ." Effect of Heat-Treated Amphotericin B on Renal and Fungal Cytotoxicity" Antimicrobial Agents and Chemotherapy, (2004) Jan;48(1):333-6.
  9.  Hartsel, S.C.  And T.R. Weiland* "Amphotericin B Binds to Amyloid Fibrils and Delays Their  Formation: A Therapeutic Mechanism? " (2003) Biochemistry, 2003-May 27;42(20):6228-33.
  10. Hartsel, S.C.,*Bauer,  E.A., *Kwong, E. H. and K. M. Wasan " The Effect of Serum Albumin on Amphotericin B Aggregate Structure and Activity." Pharmaceutical Research, 2001-Sep;18(9):1305-9.
  11. *Kwong, Evan H. , Ramaswamy, M., *Bauer,  E.A., Hartsel, S.C. and K. M. Wasan " Heat Treatment of Amphotericin B modifies its Serum Pharmacokinetics, Tissue Distribution and Renal Toxicity Following a Single Intravenous Dose to Rabbits." Antimicrobial Agents and Chemotherapy, 2001, 45: 2060-2063.
  12. Hartsel,S.C,  *Baas, B., *Bauer, E., *Foree, L.T.,  *Kindt, K.S., *Preis, H., *Scott, A.M., *Kwong, E.H., Ramaswamy, M and K. M. Wasan "Heat-Induced Superaggregation of Amphotericin B Modifies Its Interaction with Serum Proteins and Lipoproteins and Stimulation of TNF-a" J.Pharmaceutical Sci., 2001. Volume 90, Issue 2, 2001. Pages: 124-133
  13.  *Baas, B., *Kindt, K., *Scott, A., *Scott, J., *Mikulecky, P, and Hartsel, S.C. " Activity and Kinetics of Dissociation and Transfer of Amphotericin B from a Novel Delivery   Form" PharmSci , 1999  Volume   1   Issue   4   October - December 
  14. *Ruckwardt, T., *Scott, A., *Scott, J.*, Mikulecky, P. and Hartsel, S.C." Lipid and Stress Dependence of Amphotericin B Ion Selective Channels in Sterol-free Membranes" Biochimica et Biophysica Acta, 1998 Jul 17;1372(2):283-288. 
  15. Hartsel, S.C. "CHIME-Based Term Papers on the Web: A New Way to Presenting Biochemical Structural Information" Teaching with Technology Today Newsletter , 1998 II,3, March 6. 
  16. Hartsel, S.C. and Bolard, J. " Amphotericin B: New Life for an Old Drug" Trends in Pharmacological Sciences ,1996 (TiPS), 17: 445-449. 
  17. *Wolf, B.D., and Hartsel, S.C. " Osmotic Sensitizes Sterol-Free Phospholipid Bilayers to The Action of Amphotericin B" Biochimica et Biophysica Acta., 1995, 1238: 156-162. 
  18. Hartsel, S.C., *Benz, S.K.,*Ayenew, W., and Bolard, J. " Na+, K+ and Cl- Selectivity of the Permeability Pathways Induced Through Sterol-containing Membrane Vesicles by Amphotericin B and other Polyene Antibiotics."Eur. Biophysics Journal, 1994 23: 125-132 
  19. *Lambing, H.E., *Wolf, B.D. and Hartsel, S.C. "Temperature Effects on the Aggregation State and Activity of Amphotericin B."Biochimica et Biophysica Acta., 1993 1152: 185-188. 
  20. Hartsel, S.C., *Hatch, C., *Ayenew, W. " How Does Amphotericin BWork? :Studies on Model Systems." Journal of Liposome Research, 1993.3, 377-408. 
  21. Hartsel, S. C.; *Benz, S. K.; *Peterson, R. P.; and *Whyte, B. S. "Potassium Selective Amphotericin B Channels are Predominant in Vesicles Regardless of Sidedness." Biochemistry 1991, 30: 77-82. 
  22.  *Peterson, R. P.; *Benz, S. K.; *Whyte, B. S. and Hartsel, S. C. "A Kinetic Method for Measuring Functional Delivery of Amphotericin B by Drug Delivery Systems." Biochimica et Biophysica Acta, 1991, 1064: 165-168. 
  23. *Whyte, B. S.; *Peterson, R. P. and Hartsel, S. C. "Amphotericin B and Nystatin Show Different Activities on Sterol-Free Vesicles:" Biochemical and Biophysical Research Communications 1989, 164: 609-614.
  24. Hartsel, S. C.; and Cassim, J. Y. "Structure and Photodynamics of Bacteriorhodopsin in a Delipidated Contracted Lattice Form of Purple Membrane." Biochemistry 1988, 27: 3720-3724. 
  25. Hartsel, S. C.; Perkins, W. R.; McGarvey, G. J.; and Cafiso, D. S. "A Selective Cholesterol-Dependent Induction of H+/OH- Currents in Phospholipid Vesicles by Amphotericin B." Biochemistry 1988, (Accelerated Publication) 27: 2656-2660.
  26. Hartsel, S. C.; Kolodziej, B. J.; and Cassim, J. Y. "Spectral Evidence for Cytochrome o in the Brown Membrane of Halobacterium." Archives of Biochemistry and Biophysics 1988, 264: 74-81. 



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