Readings
Lecture 1 - Key Concepts in Biochemistry with a Focus on Nucleic Acids
- Recent Science article on peptide synthesis:
- Gregor Blaha, Robin E. Stanley and Thomas A. Steitz, "Formation of the First Peptide Bond: The Structure of EF-P Bound to the 70S Ribosome," Science 2009, 325, 966-970.
- Identification of DNA's role as the storage form of genetic information:
- Avery, O. T., Macleod, C. M., and McCarty, M., "Studies on the Chemical Nature of the Substance Inducing Transformation of Pneumococcal Types: Induction of Transformation by a Desoxyribonucleic Acid Fraction Isolated from Pneumococcus Type III," J. Exp. Med.1944, 79, 137–158.
- Determining the structure of DNA:
- Pauling, Linus and Corey, Robert, "A Proposed Structure for the Nucleic Acids", Proceedings of the National Academy of Science 1953, 39, 84-97.
- Wilkins, M.H.F., Stokes, A.R. and Wilson, H.R., "Molecular Structure of Deoxypentose Nucleic Acids", Nature 1953, 171, 738-740.
- Watson, J.D. and Crick, F.H.C., "A Structure for Deoxyribose Nucleic Acids", Nature 1953, 171, 737-738.
- Clarifying the "Central Dogma"
- Crick, F., "Central Dogma of Molecular Biology", Nature 1970, 227, 561-563.
Lecture 2 - Protein Structure
- Protein folding:
- Anfinsen, Christain, "Principles the Govern the folding of Proteins", Science 1973, 181, 223-230. (Anfinsen's Nobel Lecture)
- Akst, Jef, "Public solves Protein Structure: Players of an onlline game that allows users to adjust how proteins are folded have solved a decade-long protein structure mystery.", The Scientist: News & Opinion 2011 Sept. 18.
- Cooper, S., Khatib, F., Treuille, A., Barbero, J., Lee, J., Beenen, M., Leaver-Fay, A., Baker, D., Popović, Z., "Predicting protein structures with a multiplayer online game", Nature 2010 466, 756-760.
Lecture 3 - Hemoglobin: A Case Study of Protein Structure-Function Relationships
- Crystal structure of myoglobin
- Kendrew, J.C., Bodo, G., Dintzis, Parrish, R.G. and Wyckoff, H., "A Three-Dimensional Model of the Myoglobin Molecule Obtained by X-Ray Analysis", Nature 1958, 181, 662-666.
- Crystal structure of hemoglobin
- Perutz, Max, "RElation Between Structure and Sequence of Haemoglobin", Nature 1962, 194, 914-917.
Lecture 11 - Molecular Motors
- G Protein Regulation of Potassium Ion Channels
Lecture 11 - Molecular Motors
- Recent Science Special Section on Spacial Cell Biology (November 27, 2009):
- Hurtley, S., "Location, Location, Location", Science 2009, 326, 1205
- Chang, H.Y. "Anatomic Demarcation of Cells: Genes to Patterns", Science 2009, 326, 1206-1207.
- Pollard, T.D. and Cooper, J.A., "Actin, a Central Player in Cell Shape and Movement", Science 2009, 326, 1208-1212.
- Holt, C.E. and Bullock, S.L., "Subcellular mRNA Localization in Animal Cells and Why It Matters", Science 2009, 326, 1212-1216.
- Hynes, R.O., "The Extracellular Matrix: Not Just Pretty Fibrils", Science 2009, 326, 1216-1219.
- Scott, J.D. and Pawson, T.,"Cell Signaling in Space and Time: Where Proteins Come Together and When Thy're Apart", Science 2009, 326, 1220-1224.
- Shapiro, L. et al., "The Extracellular Matrix: Not Just Pretty Fibrils", Science 2009, 326, 1225-122