Lecture Materials
Unit II: Protein Structure
Lecture 2 - Protein Composition and Structure
Proteins are the workhorses of a living cell and involve themselves in nearly all of the activities that take place in a cell. Their wide range of structures are manifested by the wide range of 3–dimensional structures that they are able to possess. Proteins are linear polymers of amino acids, whose sequence is determined by the sequence of DNA base pairs in their corresponding gene. The connection between this linear sequence of amino acids for a protein and its 3-dimensional structure will be the focus of this lecture.
- Lecture 2 Overheads
- 14. September, 2012 Part 1 (Draft)
- 17. September, 2012 Part 2 (Draft)
- 19. September, 2012 Part 3 (Draft)
- 21. September, 2012 Part 4 (Draft)
- Reading:
- Berg et al., Chapter 2: Protein Composition and Structure
- Berg et al., Chapter 3.6: Three-dimensional Protein Structure Can Be Determined By X-ray Crystallography and NMR Spectroscopy
- Additional Reading
- Protein folding:
- Anfinsen, Christain, "Principles the Govern the folding of Proteins", Science 1973, 181, 223-230. (Anfinsen's Nobel Lecture)
- Cooper, S., Khatib, F., Treuille, A., Barbero, J., Lee, J., Beenen, M., Leaver-Fay, A., Baker, D., Popović, Z., "Predicting protein structures with a multiplayer online game", Nature 2010 466, 756-760.
- Akst, Jef, "Public solves Protein Structure: Players of an onlline game that allows users to adjust how proteins are folded have solved a decade-long protein structure mystery.", The Scientist: News & Opinion 2011 Sept. 18.
- Protein folding:
- Animations
- Molecular Models
- Links
- Predicting a protein's 3-dimensional structure (tertiary structure) from its amino acid sequence (primary structure).
- Rosetta@home
- Foldit Protein Folding Video Game
- Cooper, S., Khatib, F., Treuille, A., Barbero, J., Lee, J., Beenen, M., Leaver-Fay, A., Baker, D., Popović, Z., "Predicting protein structures with a multiplayer online game", Nature 2010 466, 756-760.
- Akst, Jef, "Public solves Protein Structure: Players of an onlline game that allows users to adjust how proteins are folded have solved a decade-long protein structure mystery.", The Scientist: News & Opinion 2011 Sept. 18.
- Problem Assignments
