Binding of cI repressor to the OL1 site
Lambda repressor, or cI repressor, binds operator sites as a dimer. This image shows cI repressor binding to the OL1 site via a helix-turn-helix motif.
Helix-Turn-Helix Motif
Significance of the Turn in HTH
Significant protein-protien interactions occur in the turn that contribute to the overall stability of the HTH motif. Residues Met40-Gly43 compose the turn. The backbone carbonyl of Ala37 forms H-bonds with both Gly40 and Met 42; More H-bonding occurs between the backbone carboyl of Val36 and the amide of Met40.
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