Overall Structure
The structure of porphobilinogen deaminase has been determined
by X-ray crystallography with approximate dimensions of 57 x 43
x 32(in angstroms)(5,8). The structure is composed of three domainsactive site of the enzyme. In addition, substantial conformational changes
occur as a result of cofactor binding, protecting it from catalytic
turnover and making the holoenzyme much more heat labile than
the apoenzyme(2,3,4,5,7,8).
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