Conclusions:
The TATA Binding Protein is essential for transcription, and transciption is essential for life. Binding of the TBP occurs in the minor groove of the DNA through a large area of hydrophobic interaction with the TATA box in many promotors. TBP takes advantage of the relatively weaker interactions between A's and T's (compared to G's and C's) to bend the DNA. This distortion aids the recruitment of activators to the site where RNA polymerase will bind and transcribe. TBP is first on the scene wherever the action is!