MODEL 2

Eukaryotic RNA polymerase 2 from yeast. (pdb 1nik)

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COMPARING PROKARYOTIC AND EUKARYOTIC TRANSCRIPTION

 

EUKARYOTIC TRANSCRIPTION– Detailed look at the process

 

DEADLY amanitin toxin from the Amanita phalloides mushroom

Contributions from Roger Kornberg's work in Eukaryotic Transcription leading to:

 

STEM-CELL RESEARCH

 

ANOTHER BIOLOGICAL CONTRIBUTION

A conserved RNA polymerase core structure. (A) Blocks of sequence homology between the two largest subunits of bacterial and eukaryotic RNA polymerases (70, 71) are in red. (B) Regions of structural homology between Pol II and bacterial RNA polymerase (30), as judged from a corresponding course of the polypeptide backbone, are in green. From (2)