In conclusion the pyruvate dehydrogenase complex plays a pivital role in energy metabolism. Without this enzyme complex, the body could not metabolize enough of the raw fuel to a useable form that a organism could live. The enzymatic activity of dihydrolipoyl transacetylase has formed symbiotic relation with two other enzymes and together the organism can survive. There are many inborn errors and alleleic variant that can mutate and cause many side effects in this complex, for more information travel to the OMIM. The interest in this multienzyme complex is the interactions between all three subuints which is the electrostatics that keep the enzyme in close proximity to each other. Also regenerate all the cofactors for a complete cycle. This page helps explain the interactions that take place and the structure of the enzyme.