References

1 Drake, R.R., Neamati, N., Hong, H., Pilon, A.A., Sunthankar, P., Hume, S.D., Milnes, G.W.A., and Pommier, Y. 1998. Proceedings of the National Academy of Sciences. 95: 4170-4175.

2 Engelman, A., Hickman, A.B., and Craigie, R. 1994. The Core and Carboxyl-Terminal Domains of the Integrase Protein of Human Immunodeficiency Virus Type 1 Each Contribute to Nonspecific DNA Binding. Journal of Virology. 68: 5911-5917.

3 Gerton, J.L., and Brown, P.O. 1997. The Core Domain of HIV-1 Integrase Recognizes Key Features of Its DNA Substrates. The Journal of Biological Chemistry. 272: 25809-25815.

4 Goldgur, Y., Dyda, F., Hickman, A.B., Jenkins, T.M., Craigie, R., and Davies, D.R. 1998. Three New Structures of the Core Domain of HIV-1 Integrase: An Active Site that Binds Magnesium. Proceedings of the National Academy of Sciences. 95: 9150-9154.

5 Heuer, T.S., and Brown, P.O. 1997. Mapping Features of HIV-1 Integrase Near Selected Sites on Viral and Target DNA Molecules in an Active Enzyme-DNA Complex by Photo-Cross-Linking. Biochemistry. 36: 10655-10665.

6 Heuer, T.S., and Brown, P.O. 1998. Photo-Cross-Linking Studies Suggest a Model for the Architecture of an Active Human Immunodeficiency Virus Type 1 Integrase-DNA Complex. Biochemistry. 37: 6667-6678.

7 Katz, R.A., Gravuer, K., and Skalka, A.M. 1998. A Preferred Target DNA Structure for Retroviral Integrase in Vitro. The Journal of Biological Chemistry. 273: 24190-24195.

8 Lee, S.P., and Han, M.K. 1996. Zinc Stimulates Mg2+-Dependent 3'-Processing Activity of Human Immunodeficiency Virus Type 1 Integrase in Vitro. Biochemistry. 35: 3837-3844.

9 Maignan, S., Guilloteau, J., Clement-Mella, Q., and Mikol, V. 1998. Crystal Structure of the Catalytic Domain of HIV-1 Integrase Free and Complexed with its Metal Cofactor: High Level of Similarity of the Active Site with Other Viral Integrases. Journal of Molecular Biology. 282: 359-368.

10 Woerner, A.M., and Marcus-Sekura, C.J. 1993. Characterization of a DNA Binding Domain in the C-Terminus of HIV-1 Integrase by Deletion Mutagenesis. Nucleic Acids Research. 15: 3507-3511.

11 Zheng, R., Jenkins, T.M., and Craigie, R. 1996. Zinc Folds the N-Terminal Domain of HIV-1 Integrase, Promotes Multimerization, and Enhances Catalytic Activity. Proceedings of the National Academy of Sciences. 93: 13659-13664.

 

Introduction    Processing & Joining Rxns    N-terminal domain    Core domain    C-terminal domain   

Angela Marks
Department of Chemistry

marksaf@uwec.edu

Updated: Sunday, December 13, 1998