Protein Structure - 1
Roles played by proteins:
- Structural
- Catalytic
- Transport and storage
- Regulatory
- Immunity
| Whole Genome Sequencing Projects | ||
|---|---|---|
|
Genome
|
Length (bp)
|
Date of completion
|
|
Epstein-Barr virus
|
0.172 x 106
|
1984
|
|
E. coli
|
4.8 x 106
|
1997
|
|
Yeast
|
14.4 x 106
|
1996
|
|
C. elegans
|
100 x 106
|
1998
|
|
Drosophila
|
180 x 106
|
1999
|
|
Human
|
3300 x 106
|
2001
|
New disciplines arising out of these projects:
- Bioinformatics – the systematic storage of sequence data into databases and the creation and use of tools to access these data.
- Structural Genomics – the structural counterpart of genomics.
- Genomics + Structural genomics = a complete, but static picture of a cell
- Proteomics – Following the integrated activities of proteins in cell.
NCBI's Entrez Genome Database:
- Can go here to find the status of various genome projects
Genomics
- Felix Frankfurter: "The constitution of the United States is most significantly not a document but a stream of history."
- We carry in our genomes our evolutionary history.
- In the genomics news this week:
"New Haplotype Map May Overhaul Gene Hunting" (from Oct. 28 issue of Science)
"Understanding Human Diversity" (from October 27 issue of Nature)
"A Haplotype Map of the Human Genome" (From October 27 issue of Nature
Endeavors deriving form structural knowledge of proteins:
- Interpretation of functional mechanisms of individual proteins
- Investigating the 'protein folding' problem (from Oct. 28 issue of Science)
- Investigating molecular evolution
- Predicting structures through homology modeling
- Protein engineering
- Drug design
