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Text: Whitford, David, Proteins: Structure and Function 2005, John Wiley and Sons, West Sussex, England
Chapter 1 - An Introduction to Protein Structure and Function
- Linus Pauling and Robert Corey's letter in Nature describing their proposed structure for DNA.
- James Watson and Francis Crick's letter in Nature describing their proposed structure for DNA.
- The Nobel Prize site
- Problem Set 8
Chapter 2 - Amino Acids: The Building Blocks of Proteins
- Models of the amino acids
- Computute MW/pI - Computes a molecular weight and a pI from the FASTA sequence of a polypeptide
- ProtParam - Computes a variety of chemical and physical properties for a polypeptide from its FASTA sequence, including the molecular weight, theoretical pI, amino acid composition, atomic composition, extinction coefficient, estimated half-life, instability index, aliphatic index and grand average of hydropathicity (GRAVY)
- Problem Set 8
Chapter 3 - The Three Dimensional Structures of Proteins
- Models of Phosphofructokinase
- Garnier Plot - Determine helix propensity from the FASTA sequence of a polypeptide.
- Polypeptide conformations
- Interactions
- Clathrates and hydrophobic interactions
- Packing within the tertiary structure of a protein
- Ramachandran Plot
- Structural databases
Chapter 4 - The Structure and Function of Fibrous Proteins
Chapter 5 - The Structure and Function of Membrane Proteins
- Bacteriorhodopsin
- Rhodopsin
- G-protein receptors
- Hydropathy plots
- The Respiratory Chain
- ATP Synthesis
Chapter 6 - The Diversity of Proteins
