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Introduction

Origin and Function of Cre in Phage P1

Cre and the LoxP sites

Cre Binding DNA and Facilitating Recombination

Applications

Conclusion

References

References:

[1]. Deshmukh,N.G., Van Duyne, G.D. "Structure and Mechanism in Site-Specific Recombination." Currrent Opinion in Structural Biology. Vol. 9 1999. pp.14-20.

[2]. Guo, F., Deshmukh, N.G., Van Duyne, G.D. "Structure of Cre Recombinase Complexed with DNA in a Site-Specific Recombination Synapse." Nature, Vol. 389, September 4, 1997. pp.40-46.

[3]. Guo, F., Deshmukh, N.G., Van Duyne, G.D. "Asymmetric DNA Bending in the Cre-loxP Site-Specific Recombination Synapse." Proceedings of the National Academy of Science, Vol. 96, 1999. pp. 7143-7148.

[4]. Hartung, M., Kisters-Woike, B. "Cre Mutants with Altered DNA Binding Properties." The Journal of Biological Chemistry, Vol. 273, No. 36, September 4, 1998. pp. 22884-22891.

[5]. Nagy, A. "Cre Recombinase: The Universal Reagent for Genome Tailoring." Genesis, Vol. 26, 2000. pp.99-109.

[6]. Santoro, S., Schultz,P. "Directed evolution of the site specificity of Cre recombinase." PNAS April 2, 2002. Vol. 99, No. 7, pp.4185-4190.

The complete list of PDB files for Cre recombinase is 1crx, 2crx, 3crx, 4crx, 5crx, 1drg, 1kbu, and 1f44.