Hurley JH, Chen R, Dean AM.Determinants of cofactor specificity in isocitrate dehydrogenase: structure of an engineered NADP+ --> NAD+ specificity-reversal mutant. Biochemistry 1996 May 7;35(18):5670-8

Pan H, Lee JC, Hilser VJ.Binding sites in Escherichia coli dihydrofolate reductase communicate by modulating the conformational ensemble.Proc Natl Acad Sci U S A 2000 Oct 24;97(22):12020-5

Soundar S, Danek BL, Colman RF.Identification by mutagenesis of arginines in the substrate binding site of the porcine NADP-dependent isocitrate dehydrogenase. J Biol Chem 2000 Feb 25;275(8):5606-12

Doyle SA, Beernink PT, Koshland DE Jr. Structural basis for a change in substrate specificity: crystal structure of S113E isocitrate dehydrogenase in a complex with isopropylmalate, Mg2+, and NADP. Biochemistry 2001 Apr 10;40(14):4234-41

Muro-Pastor MI, Reyes JC, Florencio FJ. The NADP+-isocitrate dehydrogenase gene (icd) is nitrogen regulated in cyanobacteria. J Bacteriol 1996 Jul;178(14):4070-6

Au SW, Naylor CE, Gover S, Vandeputte-Rutten L, Scopes DA, Mason PJ, Luzzatto L, Lam VM, Adams MJ. Solution of the structure of tetrameric human glucose 6-phosphate dehydrogenase by molecular replacement. Acta Crystallogr D Biol Crystallogr 1999 Apr;55 ( Pt 4):826-34

Mesecar AD, Stoddard BL, Koshland DE Jr. Orbital steering in the catalytic power of enzymes: small structural changes with large catalytic consequences. Science 1997 Jul 11;277(5323):202-6

Sawaya MR, Kraut J. Loop and subdomain movements in the mechanism of Escherichia coli dihydrofolate reductase: crystallographic evidence. Biochemistry 1997 Jan 21;36(3):586-603

The RCSB Protein Data Bank. www.rcsb.pdb.org. Structures 1RB2, 1QKI, 1AI2

E