Education and Training:
Ohio University, 1979 B.S. Microbiology
University of Virginia, 1985-87 American Heart Association Postdoctoral Fellow inBiochemistry/Biophysics. Preceptor: David S. Cafiso
1979-83 Teaching Associate, Department of Microbiology, Ohio State University. Responsible
for 2-4 lectures, 2-4 laboratories weekly.
1984 Presidential Research Fellow-Awarded to doctoral students demonstrating outstanding scholarship and research abilities
1985-87 American Heart Assoc. Research Fellow, Department of Chemistry, University of
1988-1992 Assistant Professor, Chemistry Department , University of Wisconsin-Eau Claire
1993-1997 Associate Professor, Chemistry Department , UW-EC
1995, 96 Research Fellow- NSF/CNRS/CIES Universite Pierre et Marie Curie and
2005-2008 Chair of Chemistry , UW-EC
1992,'98, 2000, 2006, 2007-UW-EC Outstanding Senior Award. Six of my research students (A. Scott, Ruckwardt, Peterson, Campbell, Scardino) have been honored with this highest annual award.
1993-UW System Board of Regents Teaching Excellence Award for departments/programs.Presented to the UW-EC Chemistry Department- Title :"Research as Teaching." SCH was principal author and coordinator.
1996-Diversity Award-American Ethnic Coordinating Office-.Given by the AECO annually to a faculty member who has contributed the most to campus diversity.
1996-99- Council on Undergraduate Research (CUR) Councilor in Chemistry-Nationally Elected
1999-Excellence in Scholarship Award, along with the Excellence in Teaching award, it is the highest award presented to faculty by this institution.
2001-CASE Professor of the Year (Council for Advancement and Support of Education ) -State of Wisconsin .
2002-Excellence in Undergraduate Chemical Research Award, Presented by the Department of Chemistry at the University of Indiana.
2002,2005-Kell Research Scholar Award. Two of my research students (L. Scardino, E. Bauer) have been honored with this full tuition and research stipend annual award.
2005-Wisconsin Innovation Scholar- Awarded for bringing to fruition innovative discoveries to benefit mankind and the Wisconsin economy (with David Lewis).
ACS-CPT (Committee on Professional
Training) member -ongoing.
1. Hartsel*, S.C., and D.S. Cafiso (1988) "Kinetic EPR Techniques as a Tool for Studying Membrane Active Drugs" 13th International Conference on Magnetic Resonance in Biological Systems, August 14-19, Madison, WI.
2. Whyte*, B.S. and S.C. Hartsel (1989) "Membrane Activity and Conformation of Amphotericin B in Thick Bilayers" 3rd Annual Life Sciences Symposium at Iowa State University, March 10-11.
3. Hartsel*, S.C. and B.S. Whyte (1989) "Membrane Activity and Conformation of Amphotericin B in Thick Bilayers" 22nd ACS Great Lakes Regional Meeting. May 31-June 2, Duluth, MN.
4. Benz*, S.K., Peterson, R.P., Whyte, B.S. and S.C. Hartsel (1990) "How Does Amphotericin B Really Work ?" 4th Annual Life Sciences Symposium, Iowa State University, March 9-10, Abstr. #38.
5. Benz*, S.K., Ayenew, W., Stephan, T. and S.C. Hartsel (1990) " Ion Selectivity of Amphotericin B Channels" 1st Annual Symposium for Undergraduates in Science, Engineering and Mathematics, November 2-3, Argonne National Laboratories.
6. Peterson*, R.P., Whyte, B.S., Benz, S.K. and S.C. Hartsel (1990) " A New Technique for Measuring Ion Currents Caused by Amphotericin B " 10th International Biophysics Congress, July 29- August 3, Vancouver, B.C. Abstr.#P3.4.3.
7. Benz*, W. Ayenew, T. Stephan and S.C. Hartsel. (1991) "Ion Selectivity of Amphotericin B in Channels in SUV" 35th Annual Meeting of the Biophysical Society, San Francisco, CA, February 24-28, Biophysical Journal59: 323a.
8. Hartsel*, S.K. Benz, W. Ayenew, and T. Stephan. (1991)"Ion Selectivity Profiles of Amphotericin Channels in Lipid Vesicles" American Physiological Society Conference: From Channels to Cross Bridges. Bar Harbor, Maine, July 13-16.
9. Ayenew*, J. Oertel, C. Hatch, J. Wenner and S.C. Hartsel. (1991) "Is There a Role for Sterol in Amphotericin B Channel Formation ?" 2nd Annual Symposium for Undergraduates in Science, Engineering and Mathematics, November 2-3, Argonne National Laboratories.
10. Ayenew* et al.(1992) " The Role of Sterol in Amphotericin Channel Formation" Sixth Annual Life Sciences Symposium, Iowa State University, March 6-7. Abstr. # 12.
11. "Diversity in Chemistry??!! Introducing Folk Medicine to Science Majors." S.C. Hartsel UW-EC Faculty Forum Series, Dec. 8, 1993.
12.Lambing*, H., Clark*, K. and S.C. Hartsel "To Synthesize a Killer Peptide--Or PGLa UW-EC Chemistry Department Poster Session 1993.
13. Wolf*, B. and S.C. Hartsel "Effect of Osmotic Stress on Amphotericin B Activity." UW-EC Chemistry Department Poster Session 1993.
14.Clark*, K. ,Lambing*, H., and S.C. Hartsel "Determination of the Mechanism of Action of the Antibiotic Peptide, PGLa and a Synthetic Magainin-like Peptide, Peptide K-5. T" 93rd General Meeting of the ASM, Las Vegas, NV, May 1994.
15.Wolf, * B. and S.C. Hartsel "A Molecular Harpoon? The Effect of Osmotic Stress on Amphotericin B Activity." 93rd General Meeting of the ASM, Las Vegas, NV,May 1994.
16. Wolf*, B, and S.C. Hartsel "Osmotic Stress Sensitizes Sterol-Free Phospholipid Bilayers to the Action of Amphotericin B.",1994 North Central Branch Meeting of the ASM, UW-LaCrosse, October 14..
17. Clark*,K. and S.C Hartsel, "Determination of the Mechanism of Action of the Antibiotic Peptide, PGLa and a Synthetic Magainin-like Peptide, Peptide K-5. Ibid
18. Lambing*, H. and S.C.Hartsel "Designed Peptide K5: An Efficient Agent for Transfection?", Ibid.
19.Bader*, C., Y-Y. *Cheng, C. *Dorsey, C. *Eberlein, R.*Guo, C. *Halama, K. *Hosley, E. * Morris, L. *Speigel, J. *Stephenson, A. *Sundaresan, D. *Throndson and S.C. Hartsel. "Making Biological Silicon (and Gold) from Beef Soup: A New Method to Purify Bacteriorhodopsin." UW-EC Sudent Research Day Poster Session 1996.
20. Scott*, J., *Ruckwardt, T. , *Cook , C. and S.C. Hartsel "A Source of Kidney Toxicity of Amphotericin B?". UW-EC Sudent Research Day Poster Session 1996.
21. Hartsel, S.C. "A Method for Measuring Ion Currents/Channel Selectivity for Peptides in Vesicle Systems". 1st Gordon Conference on Antimicrobial Peptides. 1997.
22. Hartsel, S.C. "Web Term Papers And Chime: A New Way Of Presenting Of Structural Information."17th Intl. Congress of Biochemistry and Molecular Biology "Biochemistry Education for the Millenium" satellite meeting, San Francisco CA, August 1997.
23. Ruckwardt*, T. , *Scott, J., S. Rychnovsky, G. Yang and S.C. Hartsel "Unusual Highly Anion Selective Channel Formed By 17-Deoxyroflamycoin" 17th Intl. Congress of Biochemistry and Molecular Biology, San Francisco CA, August 1997.
24. Scott*, J., T. , *Ruckwardt, T. and S.C. Hartsel "Formation of Ion Selective Channels in Sterol-Free Membranes by Amphotericin B" 17th Intl. Congress of Biochemistry and Molecular Biology, San Francisco CA, August 1997. WINNER- ASBMB Undergraduate Poster Competition.
25. Mikulecky ,*P. , and S.C. Hartsel "Method for Measuring Ion Currents/Channel Selectivity for Peptides in Vesicle Systems" 17th Intl. Congress of Biochemistry and Molecular Biology, San Francisco CA, August 1997. WINNER-ASBMB Undergraduate Poster Competition.
26. Hartsel, S.C., *Mikulecky, P, *Ruckwardt, T., *Scott, J., *Scott, A. " Implications of the Osmotic Stress Potentiation of Amphotericin B and Derivatives' Channel Forming Activities" (1997)Biophysical Journal74, A392.
27. Baas,* B., K. Kindt,* A. Scott*, J. Scott*, P. Mikulecky *and S. C. Hartsel. "Kinetics of Dissociation and Transfer of Amphotericin B from a Novel Delivery Form." (1999) Biophysical Journal 76:1, A383 .
28. Hartsel1 , Scott C. , Bradley Baas1 , Evan Kwong2 , Manisha Ramaswamy2 and Kishor M. Wasan2. Heat-Induced Superaggregation Of Amphotericin B (Amp B) Modifies Its Interaction With Serum Lipoproteins (Lp) And Activity Against Cholesterol-Containing Membranes. (1999) AAPS Annual Meeting, 1999, New Orleans.
29. Hartsel, Scott C. , Bradley *Baas , Evan *Kwong , Manisha Ramaswamy and Kishor M. Wasan. "Heat-Induced Superaggregation Of Amphotericin B (Amp B) Modifies Its Interaction With Serum Lipoproteins (Lp) And Activity Against Cholesterol-Containing Membranes. ",(1999) AAPS Annual Meeting, 1999, New Orleans.
30.Hartsel, S.C. "Are we not Liposomes? Amphotericin B and the De-evolution of the Liposome Concept." Liposome research Days Conference, April, 2000. J.Liposome Research 10, 227-8.
31. Kwong*,E.H., Manisha Ramaswamy1, Emily A. Bauer, Scott C. Hartsel, Kishor M. Wasan "Heat Treatment Of Amphotericin B Modifies Its Pharmacokinetics And Renal Toxicity In A Rabbit Model, And Alters Its Activity In The Presence Of Human Serum Albumin"J Inform Pharmacother 2000;3:401. seewww.informedpharmacotherapy.com/Issue3/RA/FPS%20Summer%20research%202000.htm
32.Hartsel, S.C."Kinetic Fluorescent Methods For Measuring Functional Delivery Of Membrane Active Antibiotics." (2001) Biophysical Society Meeting, Boston MA. Workshop Presentation.
33. Kwong*,E.H., Manisha Ramaswamy, Emily A.*Bauer, Scott C. Hartsel, Kishor M. Wasan "The Effect Of Serum Albumin On Amphotericin B Formulations." (2001) Biophysical Society Meeting, Boston MA. Biophyscial Journal 80 (1): 989 Part 2.
34. Emily A.*Bauer, Theodore Weiland and Scott C. Hartsel. "Amphotericin B Binds Specifically to Amyloid Fibrils" (2002) presented at Biophysical Society Meeting, San Francisco, CA
35.Scott C Hartsel, Rachel E. Nauss,
Cheney and Theodore R. Weiland. “Amphotericin B Delays
Amyloid Fibrillization.”(2003) presented at
Society Meeting, San Antonio,TX .
36. Elizabeth *Ott, Damon *Campbell, Rachel E. *Nauss, Lori *Scardino, Kristi *McNitt, Nicholas *Deprez, Scott C. Hartsel, David E. Lewis “Got the Confocal Blues? Toward a Robust Series of Organelle-Specific Fluorescence Probes “(2004) ASBMB/IUBMB Meeting, Boston
37. Rachel E. *Nauss, Scott Hartsel, Lloyd Turtinen “What Mediates the Monocyte Response to Amphotericin B?”(2004) ASBMB/IUBMB Meeting, Boston .
38. Jenifer *Schwartzhoff, David *Prall, Lindsay *Bremer, Scott Hartsel, Lloyd Turtinen “Antibody array-generated profiles of cytokine release from THP-1 monocytes exposed to different amphotericin B formulations.”(2004) ASBMB/IUBMB Meeting, Boston.
S.C. Hartsel “Micellar
Electrokinetic Capillary Electrophoresis
Analyzing Amphotericin B in Drug Delivery Formulations.”
Chromatography Forum, 25th Annual Spring Symposium.
40. *McNitt, K. A.; *Sormunen, G. J.; *Scardino, L. L.; *Campbell, D. M.; Laskowski, R. L.; Hartsel, S. C.; Lewis, D. E., Tracking cell metabolism with fluorescent naphthalimide probes. Abstracts Of Papers Of The American Chemical Society 2005, 230, U578-U579.
41. *McNitt, K. A.; *Sormunen, G. J.; *Scardino, L. L.; Ott, E. M.; Hartsel, S. C.; Lewis, D. E., Site-selective fluorescent probes for cells and organelles. Abstracts Of Papers Of The American Chemical Society 2005, 229, U213-U213.
42. *Ott, E.; *Campbell, D.; *Scardino, L.; *McNitt, K.; *Sormunen, G.; Hartsel, S.; Turtinen, L.; Lewis, D., Tracking microdomains: A new fluorescent probe for raft-watching in live cells. Faseb Journal 2005, 19, (4), A291-A291.
43. *Ott, E.; *Campbell, D.; *Scardino, L.; *Nauss, R.; *McNitt, K.; *Deprez, N.; Lewis, D.; Hartsel, S., Got the confocal blues? Toward a robust series of organelle-specific fluorescence probes. Faseb Journal 2004, 18, (8), C123-C123.
44. S.C. Hartsel, David Lewis, Lori *Scardino, "Work Smart Not Hard: Instant Visualization of Organelles" LOCI presentation, UW Madison.
Lori L. Scardino*, Vinay B. Rao*, Lee A. Behling*, Scott C. Hartsel1,
Warren H. Gallagher1, Alan A. DiSpirito2: “NMR characterization of
methanobactin in metal-bound and metal-free forms.” (2007),
ASBMB/IUBMB Meeting, Washington DC 4/31-5/2 2007.
46. Vinay B. Rao*, Lori L. Scardino*, Lee A. Behling*, Scott C. Hartsel, Marcus T. McEllistrem, Alan A. DiSpirito: “Steady state and kinetic CD studies of metal binding by methanobactin” (2007), ASBMB/IUBMB Meeting, Washington DC 4/31-5/2 2007.
47. James D. Zook*, Lee A. Behling*, Scott C. Hartsel, Alan A. DiSpirito: ” Mobilization of insoluble copper salts and minerals by methanobactin.” (2007) ASBMB/IUBMB Meeting, Washington DC 4/31-5/2.
48. Jeanne E.
Pemberton, Scott C. Hartsel.
"Building program strength and excellence through in-depth experiences."
The New ACS Guidelines for Undergraduate Chemistry Programs: Promoting Excellence and Innovation. The 236th ACS National Meeting, Philadelphia, PA, August 17-21, 2008
2. Reviewer for the Biophysical Journal, 1993-
3. Reviewer for Biochimica et Biophysica Acta, 1995-
4. Reviewer for Antimicrobial Agents and Chemotherapy,1995-
5. Reviewer for Biophysical Chemistry, 1997-
6. Reviewer for Journal of Pharmaceutical Sciences, 2001-
7. Reviewer (proposals) for the NSF-ILI Program, 1995
8. Council on Undergraduate Research (CUR) Consultant 2001-
coordinate an NSF sponsored conference “The Balanced Academic Life;
Careers at Predominantly Undergraduate Institutions”Coffman
of Minnesota, September 6-7th, 2003.
10. American Chemical
Society-Committee on Professional Training (CPT),
1. Dr. David Lewis, UW-EC. Development of new organelle-specific fluorescent probes.
2. Dr. Lloyd Turtinen, Biology Department, UWEC Dr. Turtinen and I have been collaborating on new cell culture transfection and moncyte cytokine stimulation studies.
3. Dr. Kishor Wasan- Pharmaceutics, University of British Columbia.Studies on the pharmaceutics of new drug delivery systems.
4. Dr. Edgar
University of Minnesota.NSF sponsored sabbatical
studies on analytical methodsfor analysis of drug
metabolism and mechanisms.
5. Dr. Alan Dispirito-Iowa State- Spectroscopy of novel copper-binding proteins
Grant Funding: (1988-present at UW-EC)
1. Bristol-Myers Co. Grant of the Research Corporation - " Rapid Fluorescent Probe Detection of Amphotericin B Induced Ion Fluxes" $6,771 Funded 6/88- 6/89.
2. UW-EC Grant - "Biological Membrane Channels" $ 2,000 Faculty Grants Scholar, Sp. 1989.
3. UW-EC Grant -" How Does Amphotericin B Work?" $ 2,060 Faculty Grants Scholar, 0.2 FTE. Spr. 1990
4. Research Corporation Renewal (1989) - $6,940 - Funded but declined because of NIH funding.
5. NSF-ILI - $33,852 - "Preparative HPLC" .- Co-Principal Investigator with Ochrymowycz.
6. NIH-AREA- "Ion Currents Measured by Fluorescent Probe Techniques" $96,161- Funded 5/89-6/92
7. UW-EC Faculty Development and Curriculum Improvement Grant " Biochemical Diversity: Folk Remedies to Miracle Drugs" $ 500- Funded.
8. 3M Corporation- $ 3,000(preceptor-J. Pladziewicz)
9. PRF Type B " Selectivity and Structure of Amphotericin B Channels" $ 20,000 with $ 3,000 UW-EC Match -Funded 1/92.
10.UW-EC Laboratory Modernization- With Turtinen - $28,260 Funded for Biochemistry/Molecular Biology Laboratories.
11. NSF-ILI With Gallagher, Yang, Pladziewicz "Protein Chemistry in the Undergraduate Biochemistry Curriculum" $ 26,946.- Funded, 6/92-5/94
12. NSF RUI- "Molecular Structure of Amphotericin B Channels" $88,300- Funded 11/92-8/95.
13. Sabbatical Leave, "Discovering the Determinants of Amphotericin B's Activity" granted for Spring '95.
14. University Grants Program, "Comparing the Effects of Amphotericin B on Living vs. Model Systems," $2,000 Funded.
15. Minority Faculty Research Mentor Awards through the University of Wisconsin System Institute on Race and Ethnicity T. Yang, P.I., S.C. Hartsel, Faculty Mentor " Investigation of the Guanosine-5'-triphosphate Binding to Atrial Natriuretic Factor by Nuclear Magnetic Resonance Spectroscopy" Funded.
16. NSF/CNRS INT Joint Grant for the U.S./France Research program, 1995 funded for $15,000.
17. NSF-RUI , 1996-2000 "Dynamics, Structure and Formation of Polyene Channels" $218,150. Funded.
18. UW-EC Laboratory Modernization-- $29,000 Funded for peptide synthesizer for Biochemistry/Molecular Biology Laboratories
19. UW-EC Collaborative Equipment Grant-- $13,000 Funded research spectrophotometer.
20. UWEC-SREU Program, 2001- "Cochleate Amphotericin Drug Delivery Systems" $4700
21. NSF-RUI , 2001 "The Three Facets of Amphotericin B Activity" $235,600.
22. NSF-REU , 2002 Supplement to “The Three Facets of Amphotericin B Activity" $15,000
23. NSF-REU , 2003 Supplement to"The Three Facets of Amphotericin B Activity" $15,000
22. NSF-RSEC program-sabbatical and research funding at U. of Minnesota-$38,500
23. NSF (through RSEC-program)-Funding to organize and coordinate a conference “The Balanced Academic Life; Careers at Predominantly Undergraduate Institutions” -$14,000
24. NSF-REU, 2004 Supplement to"The Three Facets of
Amphotericin B Activity" $10,000
25. UW-System Applied Research Grant, 2005 “New Probes for Fluorescence Microscopy” Co-PI with D.E. Lewis $46,000
26. NSF-CCLI, 2005 "Chromatography Opportunities for Learning and Understanding of Modern Separations (COLUMNS)" Co-PI with McEllistrem, Eierman, Yang. $100,000.
27. NSF-S-STEM , 2006 “The Excellence In Science, Technology, Engineering And Mathematics (Esteam) Scholarship Program” 2006- Michael Howe-PI, S.C. Hartsel et al , Co-PI. $500,000
28. Research Corporation- 2008-2010. "NMR and LC/TOF
Characterization of Metal Binding and Supramolecular Structure of
Methanobactin, a Novel High Affinity Chalkophore."
Total >$1,000,000 from all sources as P.I. or co-P.I