The TATA module is a short sequence of DNA, which indicates the initiation site and defines the promoter of protein-encoding genes . The consensus sequence of the TATA box is TATAAAA. These base pairs of the TATA box bind the underside of a TATA Binding Protein. TATA Binding Proteins (TBPs) are regulatory proteins that are necessary for activation of transcription . These proteins are made up of a ten-stranded beta sheet and four helices . TBP sits on top of the TATA box just as a saddle sits on a horse. The bound DNA base pairs bend severely toward the major groove, significantly altering the trajectory of the DNA by creating a 100 degree bend in the axis of the DNA. The bound TBP pries open the minor groove, forcing the TATA sequence to unwind, and thereby creating a mostly hydrophobic interface with the underside of the TATA binding protein. For more information, consult: Kim, Y. et al. (1993) Nature 365: 512-520. You may wish to manipulate this image yourself: Click and hold the left mouse button to rotate the image about the x and y axes. Rotate about the z axis by pressing the shift key and right mouse button together. The image may be translated along the x and y axes by pressing control and the right mouse button. By pressing shift and the left mouse button together, you may zoom the image in or out. Clicking the right mouse button on the image gives a menu which offers several choices, including spinning the image and changing the appearance and color of the molecule.
These base pairs of the TATA box bind the underside of a TATA Binding Protein. TATA Binding Proteins (TBPs) are regulatory proteins that are necessary for activation of transcription . These proteins are made up of a ten-stranded beta sheet and four helices . TBP sits on top of the TATA box just as a saddle sits on a horse. The bound DNA base pairs bend severely toward the major groove, significantly altering the trajectory of the DNA by creating a 100 degree bend in the axis of the DNA. The bound TBP pries open the minor groove, forcing the TATA sequence to unwind, and thereby creating a mostly hydrophobic interface with the underside of the TATA binding protein. For more information, consult: Kim, Y. et al. (1993) Nature 365: 512-520. You may wish to manipulate this image yourself: Click and hold the left mouse button to rotate the image about the x and y axes. Rotate about the z axis by pressing the shift key and right mouse button together. The image may be translated along the x and y axes by pressing control and the right mouse button. By pressing shift and the left mouse button together, you may zoom the image in or out. Clicking the right mouse button on the image gives a menu which offers several choices, including spinning the image and changing the appearance and color of the molecule.
TATA Binding Proteins (TBPs) are regulatory proteins that are necessary for activation of transcription . These proteins are made up of a ten-stranded beta sheet and four helices . TBP sits on top of the TATA box just as a saddle sits on a horse. The bound DNA base pairs bend severely toward the major groove, significantly altering the trajectory of the DNA by creating a 100 degree bend in the axis of the DNA. The bound TBP pries open the minor groove, forcing the TATA sequence to unwind, and thereby creating a mostly hydrophobic interface with the underside of the TATA binding protein. For more information, consult: Kim, Y. et al. (1993) Nature 365: 512-520. You may wish to manipulate this image yourself: Click and hold the left mouse button to rotate the image about the x and y axes. Rotate about the z axis by pressing the shift key and right mouse button together. The image may be translated along the x and y axes by pressing control and the right mouse button. By pressing shift and the left mouse button together, you may zoom the image in or out. Clicking the right mouse button on the image gives a menu which offers several choices, including spinning the image and changing the appearance and color of the molecule.
TBP sits on top of the TATA box just as a saddle sits on a horse. The bound DNA base pairs bend severely toward the major groove, significantly altering the trajectory of the DNA by creating a 100 degree bend in the axis of the DNA. The bound TBP pries open the minor groove, forcing the TATA sequence to unwind, and thereby creating a mostly hydrophobic interface with the underside of the TATA binding protein. For more information, consult: Kim, Y. et al. (1993) Nature 365: 512-520. You may wish to manipulate this image yourself: Click and hold the left mouse button to rotate the image about the x and y axes. Rotate about the z axis by pressing the shift key and right mouse button together. The image may be translated along the x and y axes by pressing control and the right mouse button. By pressing shift and the left mouse button together, you may zoom the image in or out. Clicking the right mouse button on the image gives a menu which offers several choices, including spinning the image and changing the appearance and color of the molecule.
The bound TBP pries open the minor groove, forcing the TATA sequence to unwind, and thereby creating a mostly hydrophobic interface with the underside of the TATA binding protein. For more information, consult: Kim, Y. et al. (1993) Nature 365: 512-520. You may wish to manipulate this image yourself: Click and hold the left mouse button to rotate the image about the x and y axes. Rotate about the z axis by pressing the shift key and right mouse button together. The image may be translated along the x and y axes by pressing control and the right mouse button. By pressing shift and the left mouse button together, you may zoom the image in or out. Clicking the right mouse button on the image gives a menu which offers several choices, including spinning the image and changing the appearance and color of the molecule.
For more information, consult: Kim, Y. et al. (1993) Nature 365: 512-520.
You may wish to manipulate this image yourself: