CHEMISTRY
454 Case Study Assignment/Take Home Final-Due Monday May 11, 5 PM
via email-NO EXCEPTIONS-50
pts-counted toward final exam.
Case studies are
excellent
ways to improve one's ability to integrate biochemical pathways and
concepts.
You have worked on several examples in class. Using these examples as
general
templates, I want you to construct case histories of your own.
You
may do studies of inheritied disorders or any other condition with a
significant
biochemical diagnosis (e.g.
lead poisoning). Target this for a student
at about your level of knowledge.
WHEN YOU DECIDE ON A DISORDER, TELL ME SO THAT WE CAN AVOID
DUPLICATION.
Description of Project:
- Brief 1-2 page clinical case synopsis with data. I need
to
see at least two actual bits of data (data tables, pictures,
diagrams) from the literature or made up for purposes of the case. MAKE
SURE
TO PROPERLY CITE THE SOURCE IF THE DATA IS FROM THE LITERATURE.
Especially encouraged are tabular or
visual
data (e.g. blood tests, electrophoresis gels, actual pictures of
lesions,
organs, cells or patients, etc.). You may dramatize the case a little
bit
to make it personal and interesting, but don't get too carried
away!!This
synopsis must be followed by at least three questions
(non
trivial) requiring some thought by the case study reader. Don't give it
away too easily, but be sure
it is do-able.
- Brief 1-2 page Summary or Commentary in which you solve
the
case.
Be sure to answer the questions you asked and outline the biochemical
pathways/enzyme
involved and why the symptoms are observed.
- Required: this case study should be written and
submitted
to me in MS Word format with figures, pictures,etc. inserted
in the page.
If you have any trouble doing this, I will be glad to help. The reason
I want it in this format is so that it can easily be converted to a web
page or pdf for general posting.
Also I just might use your study to baffle next year's
class. Start now.
- See this national Case
Study Database. I think they are in sore need of biochemistry
cases,
but he general format may be instructive to you!!
- Don't forget OMIM,
of course, there are thousands of interesting possibilities. Remember
OMIM will link you to abstratcts from PubMed, some of which offer free
PDF articles.
- Sometimes medical journals like JAMA
or the New England Journal of Medicine
are good places to find ideas. We get this journal in the Library.
- Here are two examples of a pretty good cases from a previous
class. One is pretty dramatic; the other is straightforward
biochemistry. Either approach works but maybe the dramatic one could be
tured into a House
or CSI
script! Example 1, Example 2
Scott Hartsel
Department of Chemistry
(715) 836-4746
hartsesc@uwec.edu