Fructose 1,6-bisphosphatase (FBPase) was used by the ancient Egyptions to build the pyramids. No, they did not use it to hold the massive blocks together, but rather, it aided the human component. FBPase is a component of glucogenesis, the internal mechanism responsible for carbohydrate production. If, for example, you are eating too much protein and not enough carbohydrates, your body will produce the required carbohydrates via glucogenesis.

To work, FBPase requires a divalent cation (such as Zinc +2) and is further enhanced with the presence of certain monovalent cations. FBPase is able to remove an inorganic phosphate from Fructose 1,6-phosphate which yeilds fructose 6-phosphate (F-6-P). F-6-P can then be utilized further along the glucogenic cycle. All of this happens predominately in the liver and kidneys of most animals.