Clicking on the following button will change the molecule from the wireframe model, seen at left, into a cartoon where the different secondary structures can be identified.
Use the following button to reveal the substrate in a spacefilling model (van der Waals radii). By pushing the following button, the picture will focus in on one of the subunits, and its ligand. |
*Please note, this representation is being done with a highly potent substrate analogue.
Structure of Cytosolic Phospholipase A2; C2 Domain
Pushing on the following button will dsplay the molecule in the cartoon model.However, the alpha helix will not be displayed. Also, the ligand of this part of cPLA2, calcium will be displayed in cyan. Notice the location of the calcium molecules and their close proximity to the end of the beta sheets, which have formed a beta barrel.
The following button will include the other parts of the molecule including the alpha helix and the hairpin loops associated with the beta sheets and alpha helix. Also, please note the proximity of the alpha helix and the calcium molecules. |
W. D. Keeton, III
University of Wisconsin -- Eau Claire
Biochemistry/Molecular Biology