Education and Training:
Ohio University, 1979 B.S. Microbiology
Ohio State University, Microbiology &Pharmacognosy,
1982 M.S. Microbiology (Pharmacognosy emphasis) Research Advisors: Bruno J. Kolodziej
and
Larry W. Robertson
Ohio State University, Microbiology &Biophysics,
1985 Ph.D. Microbiology (Biophysics emphasis) Research Advisor:
Joseph Y. Cassim
University of Virginia, 1985-87 American Heart Association
Postdoctoral
Fellow inBiochemistry/Biophysics. Preceptor:
David
S. Cafiso
Professional
Experience
1979-83 Teaching
Associate, Department of
Microbiology, Ohio State University. Responsible
for 2-4 lectures, 2-4 laboratories
weekly.
1984 Presidential
Research Fellow-Awarded
to doctoral students demonstrating outstanding scholarship and research
abilities
1985-87 American
Heart
Assoc. Research Fellow, Department of Chemistry, University
of
Virginia
1988-1992 Assistant
Professor, Chemistry
Department , University of Wisconsin-Eau Claire
1993-1997 Associate
Professor, Chemistry
Department ,
UW-EC
1995, 96 Research
Fellow- NSF/CNRS/CIES Universite Pierre et Marie Curie and
Institut Curie, Paris, France.
1997-Professor,Chemistry
Department ,
UW-EC
2005-2008 Chair of Chemistry , UW-EC
Awards/Honors
1992,'98, 2000, 2006, 2007-UW-EC
Outstanding
Senior Award. Six of
my
research students (A. Scott, Ruckwardt, Peterson, Campbell, Scardino)
have been
honored
with
this highest annual award.
1993-UW System Board of Regents Teaching
Excellence
Award for
departments/programs.Presented
to the UW-EC Chemistry Department-
Title :"Research as Teaching." SCH was principal author and coordinator.
1996-Diversity
Award-American Ethnic
Coordinating Office-.Given
by the AECO annually to a faculty member
who has contributed the most to campus diversity.
1996-99-
Council on Undergraduate Research (CUR) Councilor in Chemistry-Nationally Elected
1999-Excellence in Scholarship Award, along with the Excellence in Teaching
award,
it is the highest award presented to faculty by this institution.
2001-CASE Professor of the Year (Council for Advancement and Support of
Education
) -State of Wisconsin .
2002-Excellence in Undergraduate Chemical Research Award, Presented by the Department of Chemistry at the University of Indiana.
2002,2005-Kell Research Scholar Award. Two of my research students (L. Scardino, E. Bauer) have been honored with this full tuition and research stipend annual award.
2005-Wisconsin Innovation Scholar- Awarded for bringing to fruition innovative discoveries to benefit mankind and the Wisconsin economy (with David Lewis).
2007-
ACS-CPT (Committee on Professional
Training) member -ongoing.
Publications(*Undergraduate
Collaborators)
1. Hartsel*,
S.C., and
D.S. Cafiso (1988) "Kinetic EPR Techniques as a Tool for Studying
Membrane Active Drugs" 13th International Conference on Magnetic
Resonance in Biological
Systems, August 14-19,
Madison,
WI.
2. Whyte*,
B.S. and S.C. Hartsel (1989) "Membrane Activity and Conformation of
Amphotericin B in Thick Bilayers" 3rd Annual Life Sciences Symposium at Iowa State University, March
10-11.
3. Hartsel*, S.C.
and B.S. Whyte (1989) "Membrane Activity and Conformation of
Amphotericin B in Thick Bilayers" 22nd ACS Great Lakes Regional
Meeting. May 31-June 2,
Duluth, MN.
4. Benz*,
S.K., Peterson, R.P., Whyte, B.S. and S.C. Hartsel
(1990) "How Does
Amphotericin B Really Work ?" 4th Annual Life Sciences Symposium, Iowa State University, March 9-10, Abstr.
#38.
5. Benz*,
S.K., Ayenew, W., Stephan, T. and S.C. Hartsel
(1990) " Ion
Selectivity of Amphotericin B Channels" 1st Annual Symposium for
Undergraduates
in Science, Engineering and Mathematics, November 2-3, Argonne National
Laboratories.
6. Peterson*,
R.P., Whyte, B.S., Benz, S.K. and S.C. Hartsel (1990) "
A New
Technique for Measuring Ion Currents Caused by Amphotericin B " 10th
International
Biophysics Congress, July
29-
August 3, Vancouver, B.C. Abstr.#P3.4.3.
7. Benz*,
W. Ayenew, T. Stephan and S.C. Hartsel. (1991) "Ion
Selectivity of
Amphotericin B in Channels in SUV" 35th Annual Meeting of the
Biophysical Society, San
Francisco, CA, February 24-28, Biophysical Journal59: 323a.
8. Hartsel*, S.K.
Benz, W. Ayenew, and T. Stephan. (1991)"Ion
Selectivity Profiles of Amphotericin Channels in Lipid Vesicles"
American Physiological Society Conference: From Channels to Cross
Bridges. Bar Harbor, Maine,
July 13-16.
9. Ayenew*,
J.
Oertel, C. Hatch, J. Wenner and S.C. Hartsel.
(1991) "Is
There a Role for Sterol in Amphotericin B Channel Formation ?" 2nd
Annual
Symposium for Undergraduates in Science, Engineering and Mathematics, November 2-3, Argonne National
Laboratories.
10. Ayenew*
et
al.(1992) " The Role of
Sterol
in Amphotericin Channel Formation" Sixth Annual Life Sciences
Symposium, Iowa State
University, March 6-7. Abstr. #
12.
11. "Diversity in
Chemistry??!! Introducing Folk Medicine to Science Majors." S.C.
Hartsel UW-EC Faculty
Forum Series, Dec. 8, 1993.
12.Lambing*, H., Clark*, K. and S.C. Hartsel "To Synthesize
a
Killer Peptide--Or PGLa UW-EC Chemistry Department Poster
Session 1993.
13. Wolf*, B. and S.C. Hartsel "Effect of
Osmotic
Stress on Amphotericin B Activity." UW-EC Chemistry Department
Poster
Session 1993.
14.Clark*, K. ,Lambing*, H., and S.C. Hartsel
"Determination
of the Mechanism of Action of the Antibiotic Peptide, PGLa and a
Synthetic
Magainin-like Peptide, Peptide K-5. T" 93rd General Meeting of the
ASM,
Las Vegas, NV, May 1994.
15.Wolf, * B. and S.C. Hartsel "A Molecular
Harpoon?
The Effect of Osmotic Stress on Amphotericin B Activity." 93rd
General
Meeting of the ASM, Las Vegas, NV,May 1994.
16. Wolf*, B,
and S.C. Hartsel "Osmotic Stress Sensitizes Sterol-Free Phospholipid
Bilayers to the Action of Amphotericin B.",1994 North Central Branch
Meeting of
the ASM, UW-LaCrosse,
October 14..
17. Clark*,K.
and S.C Hartsel, "Determination of the Mechanism of Action of the
Antibiotic Peptide, PGLa and a Synthetic Magainin-like Peptide, Peptide
K-5. Ibid
18. Lambing*,
H. and S.C.Hartsel "Designed Peptide K5: An Efficient Agent for
Transfection?", Ibid.
19.Bader*, C.,
Y-Y. *Cheng, C. *Dorsey, C. *Eberlein, R.*Guo, C. *Halama, K. *Hosley,
E. * Morris,
L. *Speigel, J. *Stephenson, A. *Sundaresan, D. *Throndson and S.C.
Hartsel.
"Making Biological Silicon (and Gold) from Beef Soup: A New Method to
Purify
Bacteriorhodopsin." UW-EC Sudent Research Day Poster Session 1996.
20. Scott*,
J., *Ruckwardt,
T. , *Cook , C. and S.C. Hartsel "A Source of Kidney
Toxicity
of Amphotericin B?". UW-EC Sudent Research Day Poster Session 1996.
21. Hartsel,
S.C. "A Method for
Measuring Ion Currents/Channel Selectivity for Peptides in Vesicle
Systems". 1st Gordon Conference on
Antimicrobial Peptides.
1997.
22. Hartsel, S.C. "Web Term Papers And
Chime:
A New Way Of Presenting Of Structural Information."17th Intl.
Congress
of Biochemistry and Molecular Biology "Biochemistry Education for the
Millenium"
satellite meeting, San
Francisco
CA, August 1997.
23. Ruckwardt*,
T.
, *Scott, J., S. Rychnovsky, G. Yang and S.C. Hartsel "Unusual Highly
Anion
Selective Channel Formed By 17-Deoxyroflamycoin" 17th Intl. Congress
of
Biochemistry and Molecular Biology, San Francisco CA, August 1997.
24. Scott*,
J., T. , *Ruckwardt, T. and S.C. Hartsel "Formation of Ion
Selective Channels in Sterol-Free Membranes by Amphotericin B" 17th
Intl. Congress of Biochemistry and Molecular Biology, San Francisco CA, August 1997. WINNER-
ASBMB Undergraduate Poster Competition.
25. Mikulecky
,*P. , and S.C. Hartsel "Method for Measuring Ion Currents/Channel
Selectivity for Peptides in Vesicle Systems" 17th Intl. Congress of
Biochemistry and
Molecular Biology, San
Francisco CA, August 1997. WINNER-ASBMB Undergraduate Poster
Competition.
26. Hartsel,
S.C., *Mikulecky,
P, *Ruckwardt, T., *Scott, J., *Scott, A. " Implications of the
Osmotic
Stress Potentiation of Amphotericin B and Derivatives' Channel Forming
Activities"
(1997)Biophysical Journal74,
A392.
27. Baas,*
B., K. Kindt,* A. Scott*, J. Scott*, P. Mikulecky *and S. C.
Hartsel. "Kinetics of
Dissociation and Transfer of Amphotericin B from a Novel Delivery
Form." (1999)
Biophysical Journal 76:1,
A383
.
28. Hartsel1
, Scott C. , Bradley Baas1 , Evan Kwong2
, Manisha
Ramaswamy2 and Kishor M. Wasan2. Heat-Induced
Superaggregation
Of Amphotericin B (Amp B) Modifies Its Interaction With Serum
Lipoproteins
(Lp) And Activity Against Cholesterol-Containing Membranes. (1999) AAPS
Annual
Meeting, 1999, New Orleans.
29. Hartsel,
Scott C.
, Bradley *Baas , Evan *Kwong , Manisha Ramaswamy and Kishor M.
Wasan.
"Heat-Induced Superaggregation Of Amphotericin B (Amp B) Modifies Its
Interaction
With Serum Lipoproteins (Lp) And Activity Against
Cholesterol-Containing Membranes.
",(1999) AAPS Annual Meeting, 1999, New Orleans.
30.Hartsel, S.C.
"Are we not Liposomes? Amphotericin B and the De-evolution of the
Liposome Concept." Liposome research Days Conference, April, 2000. J.Liposome
Research 10, 227-8.
31. Kwong*,E.H.,
Manisha Ramaswamy1, Emily A. Bauer, Scott C. Hartsel, Kishor M.
Wasan
"Heat Treatment Of Amphotericin B Modifies Its Pharmacokinetics And
Renal
Toxicity In A Rabbit Model, And Alters Its Activity In The Presence Of
Human
Serum Albumin"J Inform Pharmacother 2000;3:401. seewww.informedpharmacotherapy.com/Issue3/RA/FPS%20Summer%20research%202000.htm
32.Hartsel,
S.C."Kinetic Fluorescent Methods For Measuring Functional Delivery
Of
Membrane Active Antibiotics." (2001) Biophysical Society Meeting,
Boston MA.
Workshop Presentation.
33.
Kwong*,E.H.,
Manisha Ramaswamy, Emily A.*Bauer, Scott C. Hartsel, Kishor M.
Wasan
"The Effect Of Serum Albumin On Amphotericin B Formulations." (2001)
Biophysical
Society Meeting, Boston MA. Biophyscial Journal 80 (1): 989 Part 2.
34. Emily
A.*Bauer, Theodore Weiland and Scott C. Hartsel. "Amphotericin B
Binds
Specifically to Amyloid Fibrils" (2002) presented at Biophysical
Society
Meeting, San Francisco, CA
35.Scott C Hartsel, Rachel E. Nauss,
Caitlin E.
Cheney and Theodore R. Weiland. “Amphotericin B Delays
Amyloid Fibrillization.”(2003) presented at
Biophysical
Society Meeting, San Antonio,TX .
36. Elizabeth *Ott, Damon *Campbell, Rachel E. *Nauss, Lori *Scardino, Kristi *McNitt, Nicholas *Deprez, Scott C. Hartsel, David E. Lewis “Got the Confocal Blues? Toward a Robust Series of Organelle-Specific Fluorescence Probes “(2004) ASBMB/IUBMB Meeting, Boston
37. Rachel E. *Nauss, Scott Hartsel, Lloyd Turtinen “What Mediates the Monocyte Response to Amphotericin B?”(2004) ASBMB/IUBMB Meeting, Boston .
38. Jenifer *Schwartzhoff, David *Prall, Lindsay *Bremer, Scott Hartsel, Lloyd Turtinen “Antibody array-generated profiles of cytokine release from THP-1 monocytes exposed to different amphotericin B formulations.”(2004) ASBMB/IUBMB Meeting, Boston.
39.
S.C. Hartsel “Micellar
Electrokinetic Capillary Electrophoresis
for
Analyzing Amphotericin B in Drug Delivery Formulations.”
(2003)Minnesota
Chromatography Forum, 25th Annual Spring Symposium.
40. *McNitt, K. A.; *Sormunen, G. J.; *Scardino, L. L.; *Campbell, D. M.; Laskowski, R. L.; Hartsel, S. C.; Lewis, D. E., Tracking cell metabolism with fluorescent naphthalimide probes. Abstracts Of Papers Of The American Chemical Society 2005, 230, U578-U579.
41. *McNitt, K. A.; *Sormunen, G. J.; *Scardino, L. L.; Ott, E. M.; Hartsel, S. C.; Lewis, D. E., Site-selective fluorescent probes for cells and organelles. Abstracts Of Papers Of The American Chemical Society 2005, 229, U213-U213.
42. *Ott, E.; *Campbell, D.; *Scardino, L.; *McNitt, K.; *Sormunen, G.; Hartsel, S.; Turtinen, L.; Lewis, D., Tracking microdomains: A new fluorescent probe for raft-watching in live cells. Faseb Journal 2005, 19, (4), A291-A291.
43. *Ott, E.; *Campbell, D.; *Scardino, L.; *Nauss, R.; *McNitt, K.; *Deprez, N.; Lewis, D.; Hartsel, S., Got the confocal blues? Toward a robust series of organelle-specific fluorescence probes. Faseb Journal 2004, 18, (8), C123-C123.
44. S.C. Hartsel, David Lewis, Lori *Scardino, "Work Smart Not Hard: Instant Visualization of Organelles" LOCI presentation, UW Madison.
45.
Lori L. Scardino*, Vinay B. Rao*, Lee A. Behling*, Scott C. Hartsel1,
Warren H. Gallagher1, Alan A. DiSpirito2: “NMR characterization of
methanobactin in metal-bound and metal-free forms.” (2007),
ASBMB/IUBMB Meeting, Washington DC 4/31-5/2 2007.
46. Vinay B. Rao*, Lori L. Scardino*, Lee A. Behling*, Scott C. Hartsel, Marcus T. McEllistrem, Alan A. DiSpirito: “Steady state and kinetic CD studies of metal binding by methanobactin” (2007), ASBMB/IUBMB Meeting, Washington DC 4/31-5/2 2007.
47. James D. Zook*, Lee A. Behling*, Scott C. Hartsel, Alan A. DiSpirito: ” Mobilization of insoluble copper salts and minerals by methanobactin.” (2007) ASBMB/IUBMB Meeting, Washington DC 4/31-5/2.
48. Jeanne E.
Pemberton, Scott C. Hartsel.
"Building program strength and excellence through in-depth experiences."
The New ACS Guidelines for
Undergraduate Chemistry Programs: Promoting Excellence and Innovation.
The 236th ACS National Meeting, Philadelphia, PA, August 17-21,
2008
Professional
Service
1. Council on Undergraduate Research (CUR) Councilor in Chemistry (nationally elected) 1996-1999
2. Reviewer for the Biophysical
Journal, 1993-
3. Reviewer for Biochimica et Biophysica
Acta, 1995-
4. Reviewer for Antimicrobial Agents and
Chemotherapy,1995-
5. Reviewer for Biophysical
Chemistry, 1997-
6. Reviewer for Journal of
Pharmaceutical Sciences, 2001-
7. Reviewer (proposals) for the NSF-ILI
Program,
1995
8. Council
on
Undergraduate Research (CUR) Consultant 2001-
9. Organized
and
coordinate an NSF sponsored conference “The Balanced Academic Life;
Careers at Predominantly Undergraduate Institutions”Coffman
Union, University
of Minnesota, September 6-7th, 2003.
10. American Chemical
Society-Committee on Professional Training (CPT),
2008-
Research
Collaborations
1. Dr. David Lewis, UW-EC. Development of new
organelle-specific fluorescent probes.
2. Dr. Lloyd
Turtinen, Biology
Department, UWEC Dr. Turtinen and I
have been collaborating on new cell culture transfection and moncyte
cytokine
stimulation studies.
3. Dr. Kishor
Wasan- Pharmaceutics,
University of British Columbia.Studies on the
pharmaceutics of new drug delivery systems.
4. Dr. Edgar
Arriaga- Chemistry,
University of Minnesota.NSF sponsored sabbatical
studies on analytical methodsfor analysis of drug
metabolism and mechanisms.
5. Dr. Alan Dispirito-Iowa
State- Spectroscopy of novel copper-binding proteins
Grant
Funding:
(1988-present at UW-EC)
1. Bristol-Myers
Co. Grant of the Research Corporation - " Rapid Fluorescent Probe Detection of
Amphotericin
B Induced Ion Fluxes" $6,771 Funded 6/88- 6/89.
2. UW-EC Grant - "Biological Membrane Channels" $
2,000 Faculty Grants
Scholar, Sp. 1989.
3. UW-EC Grant -" How Does Amphotericin B Work?" $
2,060 Faculty Grants
Scholar, 0.2 FTE. Spr. 1990
4. Research
Corporation Renewal (1989)
- $6,940 - Funded but
declined because of NIH funding.
5. NSF-ILI - $33,852 - "Preparative HPLC" .- Co-Principal
Investigator
with Ochrymowycz.
6. NIH-AREA- "Ion Currents Measured by Fluorescent
Probe
Techniques" $96,161-
Funded
5/89-6/92
7. UW-EC
Faculty Development and Curriculum Improvement Grant " Biochemical Diversity: Folk Remedies to
Miracle
Drugs" $ 500-
Funded.
8. 3M
Corporation- $ 3,000(preceptor-J.
Pladziewicz)
9. PRF Type B " Selectivity and Structure of
Amphotericin
B Channels" $ 20,000
with
$ 3,000 UW-EC Match -Funded 1/92.
10.UW-EC
Laboratory Modernization-
With Turtinen -
$28,260 Funded for
Biochemistry/Molecular Biology Laboratories.
11. NSF-ILI With Gallagher, Yang, Pladziewicz "Protein
Chemistry
in the Undergraduate Biochemistry Curriculum" $ 26,946.- Funded, 6/92-5/94
12. NSF RUI- "Molecular Structure of Amphotericin B
Channels"
$88,300- Funded
11/92-8/95.
13. Sabbatical
Leave, "Discovering the
Determinants of Amphotericin
B's Activity" granted for Spring '95.
14. University
Grants Program, "Comparing
the Effects of Amphotericin B on Living vs. Model Systems," $2,000 Funded.
15. Minority
Faculty Research Mentor Awards through the University of Wisconsin System
Institute on Race and Ethnicity T. Yang, P.I., S.C. Hartsel, Faculty Mentor "
Investigation
of the Guanosine-5'-triphosphate Binding to Atrial Natriuretic Factor
by
Nuclear Magnetic Resonance Spectroscopy" Funded.
16. NSF/CNRS
INT Joint Grant for the
U.S./France Research program,
1995 funded for $15,000.
17. NSF-RUI , 1996-2000 "Dynamics, Structure and
Formation
of Polyene Channels" $218,150. Funded.
18. UW-EC
Laboratory Modernization--
$29,000 Funded for peptide
synthesizer for Biochemistry/Molecular
Biology Laboratories
19. UW-EC
Collaborative Equipment Grant--
$13,000 Funded research
spectrophotometer.
20. UWEC-SREU
Program, 2001- "Cochleate Amphotericin Drug Delivery Systems" $4700
21.
NSF-RUI , 2001 "The Three
Facets of Amphotericin B
Activity"
$235,600.
22. NSF-REU , 2002 Supplement to “The Three Facets of
Amphotericin
B Activity" $15,000
23. NSF-REU , 2003 Supplement to"The Three Facets of
Amphotericin B Activity" $15,000
22. NSF-RSEC program-sabbatical and research funding at U. of
Minnesota-$38,500
23. NSF (through RSEC-program)-Funding to organize and coordinate a conference “The Balanced Academic Life; Careers at Predominantly Undergraduate Institutions” -$14,000
24. NSF-REU, 2004 Supplement to"The Three Facets of
Amphotericin B Activity" $10,000
25. UW-System Applied Research Grant, 2005 “New Probes for Fluorescence Microscopy” Co-PI with D.E. Lewis $46,000
26. NSF-CCLI, 2005 "Chromatography Opportunities for Learning and Understanding of Modern Separations (COLUMNS)" Co-PI with McEllistrem, Eierman, Yang. $100,000.
27. NSF-S-STEM , 2006 “The Excellence In Science, Technology, Engineering And Mathematics (Esteam) Scholarship Program” 2006- Michael Howe-PI, S.C. Hartsel et al , Co-PI. $500,000
28. Research Corporation- 2008-2010. "NMR and LC/TOF
Characterization of Metal Binding and Supramolecular Structure of
Methanobactin, a Novel High Affinity Chalkophore."
$34,500
Total >$1,000,000
from all sources as P.I. or co-P.I