Problems 5-Take Home Group Exam-Case studies(30 pts)

Spring 1998                                             NAME(s)                                                                   .

Due Fri. Morning, 8:00 AM May 15 (30 pts) - You are permitted to collaborate in groups as large as THREE, but no more. If you do, put all of your names above and hand in ONLY ONE REPORT. I encourage the group work process and it will make things a bit easier, but you may work alone if you must. Read the Heart Attack case history handed out and answer the questions in a report. The report must be printed not handwritten. It should be detailed enough to answer the questions, but concise. Please number the questions in the report even though this will break the flow of the narrative a bit. For some very general questions, give very brief general answers. There is no reward for writing more than you need to,but I will consider grammar and clarity of writing and thought .

Concerning questions 5 and 6, propose a known allele which could cause this disorder and which would be consistent with the specific data presented and provide a specific journal reference. Explain why it is consistent with the data. There is more than one possibility.

Don't forget to include at least two references/sources of information.

These cases will require some self-study, hunting for outside resources and discussion. Don't procrastinate!

Note: IN THIS PROBLEM AN ELEVATION OF LDL CHOLESTEROL IS A MAJOR MANIFESTATION